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Wednesday, July 29, 2020 | History

2 edition of Studies on Ricin. found in the catalog.

Studies on Ricin.

Kurt A. Kraus

Studies on Ricin.

by Kurt A. Kraus

  • 285 Want to read
  • 37 Currently reading

Published by Johns Hopkins University in Baltimore .
Written in English


Edition Notes

SeriesDissertation, Ph. D. Johns Hopkins University, Department of Chemistry:
ID Numbers
Open LibraryOL21394467M

`The perfect poison’: Ricin used in 3 recent cases Originally published at pm Updated at pm The key ingredient - castor beans - is easy to find. (8) The French also had an interest in ricin but, like early U.S. investigators, felt that it was too dangerous to study without first having an antitoxin. (9) The U.S. military's interest in ricin resurfaced around as a project of the National Defense Research Committee (10) and led to chamber and field trials at Dugway Proving Ground.

Ricin Suspected in Mail Sent to Trump and Pentagon Officials. The Secret Service said the suspicious letter to the president was not delivered to the White House, and the Pentagon quarantined all. Ricin is known to adhere galactose with its two spheres present on RTB, but Ricin besides binds to mannose in absence of brain sugar on cell membrane in some cell bound to membrane, entry into cell is driven by following proceduresHarmonizing to our survey we were able to happen 3 mechanisms which lead to ricin endocytosisa.

  Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of the mechanisms of ricin. This innovation shows that, at low doses, Ricin and Abrin inhibit the growth of hair follicles19 by selectively inducing hair follicle dystrophy, without affecting any other skin structures adversely. After successful preclinical toxicology studies, Ricin and Abrin are now ready for Phase II .


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Studies on Ricin by Kurt A. Kraus Download PDF EPUB FB2

Studies, inhalation and intravenous injection are the most lethal routes. Lethal dose for humans, by inhalation or injection, is estimated to be 5 - 10 g/kg. Because the ricin protein is large, it is probably not Studies on Ricin. book absorbed orally or through the skin.

In animal studies, most orally administered ricin is not well absorbed, and it may. Ricin is one of the most potent poisons known to science.

It is a protein produced in the seeds of the castor plant, and it targets adenine molecules—one of the “letters” of our DNA and RNA. Declassified Events: Ricin by Fouad Kazan is a war thriller but with a dark sinister twist.

The story is set in a city of Vukovar, under siege in The city is in lock down by the Serb forces, while the opposing side, the Croat army is desperately trying to hold them back/5(10).

In animal studies, ricin has been detected in tissue sections, some tissue specimens, nasal swabs, and fluids by immunologically based methods. 53,92,93 Immunologically based methods have been applied to human and animal fluid specimens in the past and have the potential to measure concentrations as low as ng/mL ( pmol/L).

However Cited by: A highly sensitive enzyme-linked immunosorbent assay (ELISA) for determination of ricin in serum is presented.

Using this method it was found that IV-injected ricin disappeared from the plasma of mice and cancer patients according to first-order kinetics. DBA mice were found to be more sensitive to ricin than C3H and B6D2 mice. I read this book at one sitting.

It is well written and constructed, and difficult to put down. It tells the true story of the ricin plot, the trial and the effect on all the key people s: 2. On September 7,the Bulgarian dissident Georgi Markov was jabbed in the leg in public on Waterloo Bridge in the middle of London by a man using a weapon built into an umbrella.

The weapon embedded a small pellet containing ricin into Markov's leg. Markov died four days later. Tests performed on ricin-suspicious samples include: Time-resolved fluorescence immunoassay: antibody binds to ricin; Polymerase chain reaction: locates and makes copies of parts of the DNA contained in the castor bean plant.

The search specifically identifies the DNA of the gene that produces the ricin protein. Laboratory Guidance. Testing for.

Ricin (/ ˈ r aɪ s ɪ n / RY-sin), a lectin (a carbohydrate-binding protein) produced in the seeds of the castor oil plant, Ricinus communis, is a highly potent toxin.A dose of purified ricin powder the size of a few grains of table salt can kill an adult human.

The median lethal dose (LD 50) of ricin for mice is around 22 micrograms per kilogram of body weight via intraperitoneal injection. Animal studies: ricin is absorbed within 2 hours by both lymphatic and blood vessels, accumulates mainly in the liver and spleen and ~20% - 45% is excreted unchanged in the feces up to 72 hours after ingestion Ingestion symptoms Symptom onset within 4 6 hours but may be as late as 10 hours Initial symptoms nonspecific: colicky abdominal pain.

Soviet Union continued to study ricin as a weapon, and inthe Iraqi government allegedly tested the use of aerosolized rici n [2]. Ricin was also used as a homicidal agent by the Soviet Komitet.

Ricin, discovered in by German scientist Peter Hermann Stillmark, is one of the most toxic substances known. It is of special concern because of its potential use as a biological weapon.

Accidental exposure to ricin is rare and results primarily from the ingestion of castor seeds. A Phase I study was carried out with ricin, a plant toxin acting by inhibiting protein synthesis, on 54 cancer patients with advanced disease. Ricin toxin is not released from the bean until it has been chewed, and digested.

Release of toxin from beans is generally in the ileum or colon. To study the effects of oral ingestion of ricin, we therefore undertook ricin-feeding studies in mice. The results shown below represent the. The Toxicology of Ricin and Abrin Toxins - Studies on Immunisation Against Abrin Toxicity [Gareth D.

Griffiths] on *FREE* shipping on qualifying offers. Ricin may be absorbed through irritated, damaged, or injured skin or through normal skin if aided by a solvent carrier. There is a potential for allergic skin reactions to occur; signs include redness (erythema), blistering (vesication), irritation, and pain.

Decontamination. Detection methods for ricin, staphylococcal enterotoxin B and T-2 toxin. J Chromatogr A ; Olsnes S. The history of ricin, abrin and related toxins. Toxicon ; Hedge, R and S.K. Podder, Studies on the variants of the protein toxins ricin and abrin, Eur.

Biochem. ;Spivak L, Hendrickson RG. Ricin. Ricin can cause nausea, vomiting, or respiratory failure depending on the route of exposure. It is a fairly slow-acting poison, taking 36 to 72 hours to kill. There is no antidote.

A general guide is 1–2 mg of ricin per gram of ground castor seed, and levels can be as high as 20 mg of ricin per gram of seeds. Ricin can be 5% of the total protein in castor beans and is present in the waste mash after the oil has been extracted.

The ricin content of the waste mash generally is 1–10% (w/w). Ricin is one of the most poisonous substances on Earth and it's scarily easy to make. Investigators still don't know why or how this poisonous compound came to be found in a Las Vegas hotel room.

Ricin is a potent toxin extracted from castor beans (Ricinus communis). There is a lot of fear and misinformation associated with this poison. The purpose of this fact sheet is to help separate fact from fiction regarding ricin poisoning.Start studying Ricin.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. These studies reveal key Golgi proteins critical for regulating glycosylation and glycolipid synthesis and provide novel therapeutic targets for blocking Stxs and ricin toxicity.

Author summary Shiga and Shiga-like toxins (Stxs) are a family of bacterial toxins and key virulence factors for the bacteria Shigella dysenteriae and.